Functional Nano-coatings on Medical Devices
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작성자 최고관리자 댓글 0건 조회 85회 작성일 19-11-18 14:52본문
Speaker: 홍진기 교수(연세대)
Date & Time: 2019. 11. 20. 수요일 17:00
Where: 융대원 D-122호
Abstract
Mesencymal stem cells (MSCs) have been mainly used for clinically research to treat diverse type of diseases containing immune-related diseases or cancer therapy. When MSCs are systemic injected into patient body, the cells are danger of high velocity of blood and attachment-deprived state due to lack of proper mechanical support, resulting in cell necrosis. To solve these problems, we have prepared multilayer film which is incorporated arginine-glycine-aspartic acid (RGD-peptide) and biomacromolecules on MSCs surface. The film did not entirely block the cell plasma membrane surface and successfully adsorbed onto cell surface confirmed by CLSM and computer dynamic simulation. The RGD peptide is a small peptide which can bind with integrin, the cellular transmembrane protein, which has various functions of cell attachment, proliferation and survival. By depositing RGD peptide incorporated films on MSCs, we found that the film coated MSCs showed significantly increase cell survival during agitation culture which is mimicked blood vessel, having cytoprotective effect of multilayer film which could be also supported by the activation of survival-related protein, Akt.
Biography
<학력>
Ph.D School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea <2010>
B.S. Chemical Engineering , Chung Ang University, Seoul, Korea <2004>
<경력>
Associate Professor, Department of Chemical and Biological Engineering, Yonsei University <2018. 3 – present>
Associate Professor, School of Chemical Engineering and Materials Science, Chung University <2013. 3 – 2018. 2>
Assistant Professor, College of Life Science, Kyung HeeUniversity <2012. 3 – 2013. 2>
Post-doctoral Associate, Department of Chemical Engineerng, M.I.T. <2010. 2 – 2012. 2>
초청자 : 융합과학부 나노융합전공 이강원 교수(031-888-9145, kangwonlee@snu.ac.kr)
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